Starting a new treatment for major depressive disorder (MDD) raises many questions, and one of the most practical is "What is the typical treatment schedule for Spravato?" Asking this before you begin can help you plan your time, set realistic expectations, and feel more confident about the process. At The Neuropsychiatry & TMS Group, we believe informed clients become empowered clients, and we take the time to ensure every individual understands what their esketamine journey will look like before the first session.
Spravato has FDA approval for adults with MDD, including those who have not responded adequately to antidepressants and those with suicidal ideation. Esketamine is administered in a certified clinical setting under direct supervision, and each visit includes a post-administration monitoring period. This structure is integral to the treatment's effectiveness, and understanding it helps set appropriate expectations from the start. To learn more about our Spravato treatment program, schedule your appointment with The Neuropsychiatry & TMS Group today.
The Spravato treatment schedule includes phases with specific session frequencies. During the induction phase, which typically spans the first four weeks of treatment, sessions occur twice weekly. This initial period is when the medication begins to take effect, and the twice-weekly schedule helps establish a foundation for response. Our team will work with you to find session times that fit your schedule as smoothly as possible during this phase.
Most individuals do not notice significant changes right away. Results from esketamine treatment generally begin to emerge over several weeks, and our providers will monitor your progress to provide a clear picture of your response.
Once the induction phase is complete, the esketamine treatment schedule shifts to a maintenance phase with less frequent sessions. During weeks five through eight, most individuals transition to one session per week. Beyond that, sessions generally continue every one to two weeks, guided by your response and your provider’s clinical judgment.
This gradual tapering is intentional. The goal is to maintain the benefits established during induction while making your schedule more manageable over time. Our providers at The Neuropsychiatry & TMS Group closely monitor your response at every stage and will work with you to determine the appropriate maintenance frequency for your situation.
Each Spravato visit involves self-administering the nasal spray in our office under the supervision of our clinical team, followed by a monitoring period of at least two hours. During that time, our providers observe you for any temporary effects and check how you are feeling. You will need a designated driver or ride service on session days, as driving is not permitted after administration.
Most individuals find the monitoring period during their Spravato treatment schedule becomes a familiar and comfortable part of their routine over time, and our team works hard to make each visit as calm and supportive as possible.
Understanding the structure of esketamine care is an important step in deciding whether it is right for you. If you have questions such as "What is the typical treatment schedule for Spravato?" or would like to learn more about our program, The Neuropsychiatry & TMS Group is here to help. Contact us today to schedule an appointment and take the next step toward the relief and well-being you deserve.
