Spravato treatment is a nasal spray used to treat persistent depression that has not responded to two or more oral antidepressants. By targeting different neural pathways in the brain, Spravato may help you find relief faster and more effectively than other therapies. Here, we will answer your questions, including those about the success rate of Spravato treatment, so that you understand this promising treatment option.
Many clinical trials have demonstrated encouraging results for Spravato when added to a standard oral antidepressant medication. Overall, studies have shown that approximately 50 to 70 percent of clients experienced significant relief from their depressive symptoms within four weeks of starting treatment.
In addition, long-term maintenance trials indicate that many clients experienced sustained symptom improvement over extended periods. This data strongly positions Spravato as an effective treatment option, significantly improving the quality of life for those struggling with more complex depression.
Success in depression studies usually requires a response that is a 50 percent drop in Montgomery-Åsberg Depression Rating Scale (MADRS) scores, or a remission, a MADRS score of 12 or less. You may experience meaningful gains well before you meet either threshold, but these benchmarks can give you and your clinician a common language for progress.
On day 28 in a large Spravato clinical trial, roughly half the participants were responders, and more than one-third were already in remission. This reinforces the week-four landmark as a turning point for Spravato therapy.
Every brain is unique, so your chances of success depend on more than a headline number. Your response to Spravato treatment may be affected by your age, the extent of your depression, and any co-existing health conditions. Researchers did notice that having co-existing anxiety did not impact Spravato’s antidepressant benefit, as both anxious and non-anxious groups improved at comparable rates.
Your adherence to oral partner antidepressants is also a factor. With this in mind, our provider will modify your treatment plan as needed instead of following a rigid template. In addition, building up emotional and practical support systems can positively influence Spravato’s effects, highlighting the importance of a comprehensive care environment.
Before you arrive for each in-clinic Spravato therapy session, consider applying the following strategic habits to improve your success:
You may notice that these steps revolve around preparation, readiness, and open communication. When you and your care team stay aligned, you can catch problems earlier and extend positive momentum.
If traditional antidepressants have left you feeling discouraged, Spravato’s success rates may offer you a restored, genuine sense of hope. With data pointing to quick gains and durable remission for many, you may be just weeks away from reclaiming your life with Spravato.
Reach out today and learn more about our approach to exploring advanced options for depression therapy. The expert providers at The Neuropsychiatry & TMS Group are here for you and will gladly answer all your questions.
