How Long Can You Stay on Spravato?

If you are currently taking or considering starting Spravato, you may have questions about the length of treatment. At The Neuropsychiatry & TMS Group, we are dedicated to helping you address your mental health concerns with open communication, in-depth guidance, and evidence-based treatment designed for your unique needs. If you are wondering how long you can stay on Spravato, contact our providers and schedule an appointment today.

What is Spravato?

Spravato, a nasal spray containing esketamine, works by activating NMDA receptors and increasing glutamate in your brain. This process improves communication between brain cells and supports mood regulation. The treatment is FDA-approved for managing major depressive disorder (MDD) in adults, especially when traditional therapies such as oral antidepressants or talk therapy have not provided adequate relief. Unlike standard medications that may take weeks to show improvement, some patients experience changes in mood or outlook within hours to days of treatment with Spravato. While the length of Spravato treatment varies, it has been considered an effective, non-invasive option for managing depressive symptoms and restoring daily functioning.

Understanding the Treatment Course of Spravato

Administered under supervision at our Brandon, Tampa, or St. Petersburg clinic, Spravato treatment typically begins with twice-weekly sessions for the first four weeks. This “induction phase” lasts 14 rounds of treatment and is designed to give your body time to adjust and assess how you respond to the medication. During the next eight weeks, sessions are often reduced to once weekly and once bi-weekly. After this initial treatment period, your provider will reassess and tailor the frequency of your Spravato sessions based on your response and ongoing needs. For many patients, Spravato maintenance sessions are scheduled every one to two weeks to help sustain results. Others may benefit from extended maintenance care for months or even years. Because depression is a chronic condition for many, your treatment plan may evolve over time, and our providers will carefully adjust your Spravato schedule so that you feel supported at every stage.

Is Long-Term Usage Safe?

The ability to stay on Spravato long term depends on several factors, including your overall health, your treatment response, and how well your depressive symptoms remain under control. Ongoing research and clinical experience suggest that Spravato can be used safely with continued monitoring. At The Neuropsychiatry & TMS Group, we place a strong emphasis on safety and collaboration. Our providers will check in regularly to evaluate your progress, address side effects such as dizziness or fatigue, and adjust your treatment plan when needed. We also coordinate with any other healthcare professionals involved in your care to ensure Spravato complements your overall wellness plan.

Supporting You Beyond Treatment Sessions

Treatment with Spravato works best when combined with other supportive strategies, such as psychotherapy, lifestyle changes, and consistent follow-up care. Our team can help you integrate these approaches into your daily life so you feel more confident in managing depression both inside and outside the clinic. Many patients find that having a full-circle approach gives them the best chance at long-term improvement. In addition to mood stabilization, patients may notice improvements in sleep quality, energy levels, and the ability to concentrate. These benefits can build over the duration of your Spravato treatment and help restore a sense of normalcy, motivation, and hope for the future.

Contact Us to Learn How Long You Can Take Spravato

Spravato can provide life-changing relief from symptoms of depression. Whether you have just decided to start, continue, or end therapy, you do not need to manage your treatment alone. Our understanding staff is here to support you and provide guidance on your next steps. Contact us today to discover how long you can stay on Spravato and schedule an appointment with our compassionate providers.